Liquid Propolis Colorectal Cancer

Most colorectal cancers,

It usually starts as a polyp that starts from the inner lining of the colon or rectum and grows towards the center. Some polyps are not dangerous, but some eventually develop into adenomas and can eventually cause cancer. A study investigating the chemopreventive effects of propolis gelam and nenas monofloral against colon cancer cell lines found that it inhibited the proliferation of colon cancer cells. Hydrogen peroxide-induced inflammation was used to examine the effect of propolis in colon cancer cells. The results showed that the effects of propolis reduced inflammation in cancer cells. Another study was conducted to investigate the apoptotic effects of propolis on colon cancer cell lines. The study confirmed its antiproliferative effect in these cells. In addition, a significant antiproliferative effect was observed against colon cancer cells at high phenolic concentrations (such as those of quercetin and flavonoids).

The molecular mechanisms that cause the antiproliferative and anticancer effects of propolis include cell cycle arrest, activation of the mitochondrial pathway, stimulation of mitochondrial outer membrane permeability, induction of apoptosis, modulation of oxidative stress, reduction of inflammation, modulation of insulin signaling, and inhibition of angiogenesis in cancer cells. Additionally, honey shows potential effects on cancer cells by modulating cancer-promoting proteins, genes, and cytokines.